Influences on allergic mechanisms through gut, lung, and skin microbiome exposures
Andrea M. Kemter and Cathryn R. Nagler
Department of Pathology and Committee on Immunology, The University of Chicago, Chicago, Illinois, USA.
Address correspondence to: Cathryn R. Nagler, The University of Chicago, 924 East 57th Street, JFK R410, Chicago, Illinois 60637, USA. Phone: 773.702.6317; Email: cnagler@bsd.uchicago.edu.
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Department of Pathology and Committee on Immunology, The University of Chicago, Chicago, Illinois, USA.
Address correspondence to: Cathryn R. Nagler, The University of Chicago, 924 East 57th Street, JFK R410, Chicago, Illinois 60637, USA. Phone: 773.702.6317; Email: cnagler@bsd.uchicago.edu.
Find articles by Nagler, C. in: JCI | PubMed | Google Scholar
First published February 25, 2019 - More info
J Clin Invest. 2019;129(4):1483–1492. https://doi.org/10.1172/JCI124610.
© 2019 American Society for Clinical Investigation
In industrialized societies the incidence of allergic diseases like atopic dermatitis, food allergies, and asthma has risen alarmingly over the last few decades. This increase has been attributed, in part, to lifestyle changes that alter the composition and function of the microbes that colonize the skin and mucosal surfaces. Strategies that reverse these changes to establish and maintain a healthy microbiome show promise for the prevention and treatment of allergic disease. In this Review, we will discuss evidence from preclinical and clinical studies that gives insights into how the microbiota of skin, intestinal tract, and airways influence immune responses in the context of allergic sensitization.
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